I've just released Reddit Content Filter version 0.5. Reddit Content Filter is a Greasemonkey scripts that allows you to filter unwanted articles on Reddit by author, domain, or title.
This release has been updated to work with the new Reddit layout. I've also improved the interface; there is now a row of buttons across the top-right corner of the screen that allow you to reconfigure filters and toggle the visibility of hidden articles without reloading the page.
User Scripts seems to have hosed my existing account, so for now you can install the script from the link below:
Update: I've cross-posted this release note over on Reddit. Feel free to comment over there.
Update 2: Now available on User Scripts too.